منابع مشابه
(2S,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidine-2-carboxylic acid [(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)proline]
The crystal structure of the title compound, C(6)H(11)NO(5), establishes the relative configuration at the four stereogenic centres; the absolute configuration is determined by the use of d-glucuronolactone as the starting material for the synthesis. Mol-ecules are linked by inter-molecular O-H⋯O and N-H⋯O hydrogen bonds into a three-dimensional network, with each mol-ecule acting as a donor an...
متن کاملMisincorporation of the proline homologue Aze (azetidine-2-carboxylic acid) into recombinant myelin basic protein.
We have evaluated the effects of the proline homologue Aze (1) (azetidine-2-carboxylic acid) on growth of Escherichia coli strains used to over-express recombinant forms of murine myelin basic protein (rmMBP), and on the degree of misincorporation. Addition of Aze to minimal media resulted in severe diminution of growth rate, but rmMBP could still be produced and purified. Mass spectrometry ind...
متن کاملEffects of the Proline Analog l-Thiazolidine-4-carboxylic Acid on Proline Metabolism.
The effect of various proline analogs on proline oxidation in mitochondria isolated from etiolated barley (Hordeum vulgare) shoots was investigated. Of the analogs tested, only l-thiazolidine-4-carboxylic acid (T4C) was an effective inhibitor. T4C (1 millimolar) inhibited proline (10 millimolar) -dependent 0(2) uptake an average of 67%. T4C was also oxidized to some degree (12.9 nanoatoms oxyge...
متن کاملTheoretical and NMR Conformational Studies of β-Proline Oligopeptides With Alternating Chirality of Pyrrolidine Units
1 Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia, Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia, 3 Institute of Organic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany, 4 Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany, 5 Institute of Physiologic...
متن کامل2-(2,6-Dichlorobenzyl)pyrrolidine-1,3-dione
In the title compound, C(11)H(9)Cl(2)NO(2), the dihedral anngle between the mean planes of the aromatic ring and the twisted pyrrolidinedione ring is 79.98 (9)°.
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ژورنال
عنوان ژورنال: Synlett
سال: 2003
ISSN: 0936-5214,1437-2096
DOI: 10.1055/s-2003-37536